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Unité
ANA-MARIA LENNON / OLIVIER LANTZ
Immunité et Cancer (U932)

Créée en 2005, l’Unité U932 INSERM est composée de 10 équipes, réparties sur deux bâtiments (Hôpital Curie et Bâtiment Constant-Burg, rue Lhomond), regroupant environ 120 personnes.

Les équipes de l’Unité tentent de mieux comprendre les réponses immunitaires, et d’apprendre au système immunitaire à mieux lutter contre les agents pathogènes et/ou les tumeurs. Les projets de recherche vont de l’immunologie fondamentale à l’immunothérapie translationnelle et à l’immunothérapie clinique chez des patients atteints de cancer.

 

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334
Publications depuis 2017
7
ERC depuis 2008
3
start-ups
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Événements scientifiques
5 Sep
2022
Séminaire
14h-15h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
CAR T cell therapy - The long-sought cure for cancer
Enticing the immune system to regain control of a patient’s malignancies has remained a seemingly unsurmountable challenge until discoveries on T cell costimulation and -inhibition provided the critical insight to overcome passive and active immune resistance by cancers. Equipping a patient’s T cell with the ability to target tumor cell lineage-specific surface proteins using an engine
21 juin
2022
Séminaire
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
A-type lamins in T cell-mediated immune response
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense fibrous protein meshwork located in the nuclear interior. Lamin A/C proteins regulate nuclear mechanics and structure and control cellular signaling, gene transcription, epigenetic regulation, cell cycle progression, cell differentiation, and cell migration. The immune system is composed of the innat
13 juin
2022
Séminaire
14h-16h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Insider Advice from a Scientific Editor
She will speak about the way to build a high-impact paper and talk about some myths and strategies related to the publication process during 30 to 45 min followed by questions.

She will describe her job as a scientific editor and the evolution of the field with the development of Open Access Journals and the new “Review Commons” process of peer reviewing.

Interesting talk for all
13 juin
2022
Séminaire
09h-10h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
TCRen: predicting TCR-peptide recognition based on residue-level pairwise statistical potential
T cell receptor (TCR) recognition of foreign peptides presented by major histocompatibility complex (MHC) proteins is a crucial step in triggering the adaptive immune response. Prediction of TCR:peptide recognition is important for many clinically relevant problems: prediction of cross-reactivity of TCRs used in adoptive T-cell-based therapies, identification of targets for antigen-specific therap
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